Pyrazinamide Research Paper
Pyrazinamide is a prodrug. Pyrazinamidase . PZA enters passively into tubercle bacilli through an ATP-dependent transport system.As soon as PZA enters the bacilli it is coverted into acid (POA), by the enzyme pyrazinamidase (PZase)and reaches high concentrations in the bacterial cytoplasm due to an inefficient efflux system. The accumulation of pyrazinoic acid decreases the intracellular pH to levels that cause the inactivation of enzymes-such as fatty acid synthase I, which plays a fundamental role in synthesizing fatty acids-and, consequently, the impairment of mycolic acid