2-Naphthol Synthesis Lab Report
All the reagents and solvents used for synthesizing the title compound were of Analar grade (Merck) and were used as such without further purification. The 2-naphthol derived Mannich base 1-((4-methylpiperazin-1-yl)(phenyl)methyl)naphthalen-2-ol (MPN) was synthesized according to the general procedure described in the literatures [13, 14]. The 2-naphthol (4.33 g, 0.03 mol) was dissolved in 30ml of ethanol and it was mixed with
N-methylpiperizine (3.0 mL, 0.03 mol) by continuous stirrer at room temperature until a clear solution was obtained. The benzaldehyde (3.0 mL, 0.03 mol) was added slowly to this mixture with constant stirring. After 48 hours of continuous stirring, a white color precipitate was formed and it was washed with distilled water several times and dried in the air oven at 60 °C. The reaction scheme of MPN is shown in Figure 1. …show more content…
Slow evaporation technique was employed to obtain the single crystal. The acetonitrile was taken in a beaker and the synthesized material was added to prepare the saturated solution. Then the solution was covered by a perforated sheet and kept separately for slow evaporation without any disturbance at room temperature. The crystal growth condition was optimized and grown crystals were purified by successive recrystallization process. Due to the spontaneous nucleation, colorless single crystals were obtained in a period of 15 - 20 days. Figure 2 shows the photograph of as grown single crystal of MPN. The theoretical Bravais, Friedel, Connay and Harker (BFDH) morphological [38] method of MPN crystal with indexed (hkl) planes was determined using the unit cell and positional coordinates of MPN by MERCURY software program [39]. The MPN crystal shows well developed morphology with several habit faces, for each face its parallel Friedel plane is also present in the grown crystal which is shown on Figure
N-methylpiperizine (3.0 mL, 0.03 mol) by continuous stirrer at room temperature until a clear solution was obtained. The benzaldehyde (3.0 mL, 0.03 mol) was added slowly to this mixture with constant stirring. After 48 hours of continuous stirring, a white color precipitate was formed and it was washed with distilled water several times and dried in the air oven at 60 °C. The reaction scheme of MPN is shown in Figure 1. …show more content…
Slow evaporation technique was employed to obtain the single crystal. The acetonitrile was taken in a beaker and the synthesized material was added to prepare the saturated solution. Then the solution was covered by a perforated sheet and kept separately for slow evaporation without any disturbance at room temperature. The crystal growth condition was optimized and grown crystals were purified by successive recrystallization process. Due to the spontaneous nucleation, colorless single crystals were obtained in a period of 15 - 20 days. Figure 2 shows the photograph of as grown single crystal of MPN. The theoretical Bravais, Friedel, Connay and Harker (BFDH) morphological [38] method of MPN crystal with indexed (hkl) planes was determined using the unit cell and positional coordinates of MPN by MERCURY software program [39]. The MPN crystal shows well developed morphology with several habit faces, for each face its parallel Friedel plane is also present in the grown crystal which is shown on Figure